Role of Nucleobindin 1 in Clozapine-Induced Neuroprotection in MPTP-Treated Mice Models / (Record no. 607207)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01480nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bhatti, Rohama Makmas |
| 245 ## - TITLE STATEMENT | |
| Title | Role of Nucleobindin 1 in Clozapine-Induced Neuroprotection in MPTP-Treated Mice Models / |
| Statement of responsibility, etc. | Rohama Makmas Bhatti |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 64p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A possible candidate for neuroprotection has recently been identified as NUCB1, a multifunctional<br/>protein involved in calcium homeostasis and stress response. In this work, the effect of coadministering clozapine and MPTP on the survival of dopaminergic neurons was assessed. To<br/>determine the degree of neuroprotection, histological analyses and behavioral evaluations were<br/>done. The expression and distribution of NUCB1 in the central nervous system of mice with a<br/>particular focus on the brain by using RT-PCR was analyzed. Our results showed that mice treated<br/>with MPTP had considerably different levels of NUCB1 expression in the brain than mice treated<br/>with clozapine. These findings provide interesting directions for future neuroprotective approaches<br/>in the setting of MPTP-induced neuronal injury and shed light on the possible therapeutic<br/>implications of NUCB1 in reducing neurodegeneration in Parkinson’s disease. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/39581">http://10.250.8.41:8080/xmlui/handle/123456789/39581</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 12/07/2023 | 610 | SMME-TH-938 | Thesis |