Ciprofloxacin-Gold Nanoparticles Loaded Polymeric Membrane as a Novel Antibacterial Wound Dressing against Diabetic Foot Ulcer Infection / (Record no. 607249)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02046nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Malik, Hadiya |
| 245 ## - TITLE STATEMENT | |
| Title | Ciprofloxacin-Gold Nanoparticles Loaded Polymeric Membrane as a Novel Antibacterial Wound Dressing against Diabetic Foot Ulcer Infection / |
| Statement of responsibility, etc. | Hadiya Malik |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 77p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Nano-based wound dressings, with improved features such as controlled release of therapeutic<br/>drug and increased antibacterial activity, play a significant role in supporting efficient and fast<br/>wound healing. This research describes a unique method for creating a polymeric wound<br/>dressing material to address the problems of diabetic foot ulcers (DFUs) infection. The research<br/>focuses on introducing ciprofloxacin-loaded gold nanoparticles (CIP-AuNPs) into the dressing<br/>material using gum tragacanth (GT) and polyvinyl alcohol (PVA). Ultraviolet-Visible<br/>spectrophotometry (UV), Fourier transform Infrared Spectroscopy (FTIR), Scanning Electron<br/>Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), Contact Angle<br/>Measurement, and Mechanical Test were used to characterize the fabricated membranes<br/>Biocompatibility, Drug Release Efficiency, and Antibacterial Efficacy against E. coli were all<br/>investigated. In Vitro results showed the effective synthesis of CIP-AuNPs as well as the<br/>improved mechanical characteristics of the membranes. The CIP-loaded membrane demonstrated<br/>low cytotoxicity and prolonged ciprofloxacin release. The antibacterial activity of the CIP-loaded<br/>membrane was substantial. In vivo testing on rat model showed the valuable and efficient results<br/>of CIP-loaded membrane on wound healing and potential for the clinical trials. This research<br/>suggests a viable wound dressing material for the treatment of DFUs.<br/> |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Engineering (BME) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/38324">http://10.250.8.41:8080/xmlui/handle/123456789/38324</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 12/08/2023 | 610 | SMME-TH-921 | Thesis |