Prevention of Diabetes-Associated Cognitive Impairment through the Administration of Herbal Products / (Record no. 607295)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01785nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Riaz, Hibba |
| 245 ## - TITLE STATEMENT | |
| Title | Prevention of Diabetes-Associated Cognitive Impairment through the Administration of Herbal Products / |
| Statement of responsibility, etc. | Hibba Riaz |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 67p. ; |
| Other physical details | Soft Copy |
| Dimensions | 30cm. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The condition of long-term high blood glucose concentration i.e., chronic hyperglycaemia<br/>resulting from deficiency of insulin leads to Diabetes Mellitus. This deficiency leads to metabolic<br/>disturbances notably in carbohydrate, protein and lipid metabolism. The number of diabetic<br/>patients has significantly increased in the past few years. An association between Type 1 Diabetes<br/>Mellitus (TIDM) and cognitive impairment has been previously reported and is extremely<br/>dominant in ageing patients. We confirmed that TIDM mice induced by streptozotocin (STZ)<br/>injections presented impairments in working and spatial memory. Long-term potentiation (LTP)<br/>induction defects and synaptic loss were also observed in these mice. Modified levels of synaptic<br/>proteins i.e. N-methyl-D-aspartic acid receptor (NMDAR) subunit NR2A were found in the<br/>cortical region. We administered natural herbs including Nigella sativa and Cassia angustifolia<br/>post-STZ injections in diabetic mice and observed improvements in memory, neuronal loss, and<br/>synaptic proteins even with the retention of hyperglycaemia. Incorporation of these herbs in the<br/>diet of diabetic and pre-diabetic patients may improve debilitating cognitive deficits<br/>associated with TIDM. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/37075">http://10.250.8.41:8080/xmlui/handle/123456789/37075</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 12/11/2023 | 610 | SMME-TH-901 | Thesis |