Saikosaponin B2 Prevents Against BAP-induced Lungs Cancer in Mouse Model by Regulating Oxidative Stress / (Record no. 608895)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01936nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Imran, Jannat |
| 245 ## - TITLE STATEMENT | |
| Title | Saikosaponin B2 Prevents Against BAP-induced Lungs Cancer in Mouse Model by Regulating Oxidative Stress / |
| Statement of responsibility, etc. | Jannat Imran |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2022. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 83p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Cancer of the lungs is the second most frequent form of cancer overall and has the<br/>greatest mortality rate because to its severe pathological abnormalities. In lung cancer,<br/>abnormal cell proliferation causes the alveolar duct to clot. Lung cancer is difficult to<br/>treat due to its clinical and biological heterogeneity, which necessitates the development<br/>of new therapeutic approaches or the refinement of existing ones. To investigate this,<br/>saikosaponin b2 was administered to mice with lung cancer caused by B(a)P. (SSb2).<br/>BAP is considered a group one carcinogen by the International Agency for Research on<br/>Cancer (IARC). Therefore, B(a)P may play a role in producing lung cancer. Albino<br/>balb/c mice were given B(a)P on alternate days over a 4-week period to induce cancer,<br/>with DMBA given weekly to encourage tumor growth. Beginning in the third week,<br/>SSb2 was given daily for twenty days. The drug's potential anti-cancer effects were<br/>studied by examining hepatic biomarkers, lung histology, and oxidative stress indicators.<br/>Increases in SOD, CAT, GST, and GSH levels accompanied by decreases in MDA levels<br/>and enhanced B(a)P detoxification after SSb2 treatment, which also improved liver<br/>function. Histopathology data showed that as compared with the B(a)P alone group, SSb2<br/>reduced inflammation, membrane blebbing, and alveolar structure began returning to<br/>normal. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Adeeb Shehzad |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/30889">http://10.250.8.41:8080/xmlui/handle/123456789/30889</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 04/19/2024 | 610 | SMME-TH-782 | Thesis |