Bifunctional and Synergic Surface Modifications of Biomedical Implants for Improved Biocompatibility / (Record no. 610796)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03345nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610. |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hassan, Sadia |
| 245 ## - TITLE STATEMENT | |
| Title | Bifunctional and Synergic Surface Modifications of Biomedical Implants for Improved Biocompatibility / |
| Statement of responsibility, etc. | Sadia Hassan |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 381p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm. |
| Accompanying material | 2023. |
| 500 ## - GENERAL NOTE | |
| General note | Background: Development and fabrication of medical implants to monitor or treat the<br/>damaged or missing body part is becoming an important field of biomedicine because of<br/>increasing aged population which is more susceptible to chronic diseases. Tissue damage<br/>occurring during the implantation process, coupled with the prolonged presence of a<br/>foreign device within the body, can set off a series of reactions. These reactions, in turn,<br/>can culminate in the onset of foreign body responses, ultimately leading to a loss of<br/>functionality and potential implant failure. Damage to surrounding tissue during<br/>implantation, combined with the extended presence of foreign devices in the body, can<br/>trigger a cascade of events. These events may give rise to foreign body reactions that, in<br/>turn, result in the loss of implant functionality and potential implant failure. Historically,<br/>different techniques were employed to suppress inflammation and the formation of fibrous<br/>encapsulation around implants, with the goal of ensuring their sustained, long-term<br/>functionality. Nevertheless, these approaches often addressed only one facet of the<br/>problem, leaving the implants susceptible to disruption by other biological phenomena.<br/>Thus, there is a need to develop multifunctional biomedical devices comprising of different<br/>biomaterials which could synergically work and inhibit more than one biological activity.<br/>Objective: The objective of this study was to develop a multifunctional biomedical implant<br/>surface which had anti-coagulation, anti-thrombosis, anticorrosive and anti-material<br/>leaching properties.<br/>Methodology: A combination of passive and active modifications was proposed which<br/>could provide an anti-corrosive and anti-coagulant surface, respectively. First, different<br/>surface modifications including electropolishing, graphite coating and micropores<br/>formation were carried out and their hemocompatibility, anti-corrosive and anti-material<br/>leaching properties were compared and most suitable candidate was selected. Then,<br/>biological active modifications were fabricated to inhibit the thrombo-inflammatory<br/>cascades through pharmacological active ingredients. Novel ingredients from natural<br/>sources were embedded into different polymeric matrixes and their degradation, release<br/>kinetics, antioxidative potential and anticoagulation properties were compared and the<br/>most suitable candidate was selected. The mechanism of action of shortlisted candidate was<br/>predicted through the tools of bioinformatics and presence of pharmacological active<br/>ingredients responsible for inhibition of coagulation cascade were confirmed through GC-<br/>vi<br/>MS analysis. Afterwards, the passive and active modifications were combined, and their<br/>synergic effects were evaluated |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PhD Biomedical Sciences |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Murtaza Najabat Ali |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/43911">http://10.250.8.41:8080/xmlui/handle/123456789/43911</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 08/06/2024 | 610. | SMME-Phd-30 | Thesis |