Calcium Phosphate Based Coating of Hard tissue implants / (Record no. 611623)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02351nam a22001697a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | NUST |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Tariq ,Komel |
| 245 ## - TITLE STATEMENT | |
| Title | Calcium Phosphate Based Coating of Hard tissue implants / |
| Statement of responsibility, etc. | Komel Tariq |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad: |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST. |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 77p. ; |
| Other physical details | Soft Copy, |
| Dimensions | 30cm. |
| 500 ## - GENERAL NOTE | |
| General note | Implant-associated infections remain a significant challenge in orthopaedic and dental<br/>implants because they frequently result in implant failure, higher patient morbidity and<br/>significant healthcare costs. One of the primary pathogens responsible for these IAIs is<br/>Staphylococcus aureus, known for its potential to make biofilms on the surfaces of<br/>implants. Hard tissue implants play a crucial role in modern medicine, facilitating the<br/>restoration of damaged or lost tissues and improving the quality of life for millions of<br/>patients worldwide. In this research, we propose a novel approach to enhance the<br/>antibacterial properties of hard tissue implants by fortifying their surfaces with calciumdoped zinc oxide (Ca-ZnO) nanoparticles through biomimetic calcium phosphate coating.<br/>Hydroxyapatites [Ca10(PO4)6(OH)2, Hap] are the main constituents of bones and<br/>tissues. Calcium phosphate has been playing a role in human hard tissue bio-engineering<br/>because of its high biocompatibility and biodegradability. This study aimed to develop<br/>Ca2+-dopedZnO nanoparticles (NPs) and investigate their antibacterial properties against<br/>microorganisms like Staphylococcus aureus. Ca/ZnO NPs are synthesized by the coprecipitation method and subsequently characterized by scanning electron microscopy<br/>(SEM), X-ray diffraction (XRD), UV-vis spectroscopy, and Fourier transform infrared<br/>spectroscopy (FT-IR).Significant enhancement in the antibacterial properties was<br/>observed in alkaline and heat treated disc coated with Ca-doped ZnO NPs for 14 days<br/>compared to 7 days and discs coated with bare ZnO NPs (Staphylococcus aureus,<br/>p=<0.0001).These findings suggest that calcium phosphate-based biomimetic coatings,<br/>doped with calcium-doped ZnO NPs show great potential for reducing the risk for<br/>implant-associated infections. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor: Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href=" http://10.250.8.41:8080/xmlui/handle/123456789/46683"> http://10.250.8.41:8080/xmlui/handle/123456789/46683</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 09/20/2024 | 610 | SMME-TH-1067 | Thesis |