Unlocking Neurogenesis: PRGF Regenerative Therapy and the role of Tau Protein in Neurodegenerative Disease Models / (Record no. 612947)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02309nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Salih, Aqsa |
| 245 ## - TITLE STATEMENT | |
| Title | Unlocking Neurogenesis: PRGF Regenerative Therapy and the role of Tau Protein in Neurodegenerative Disease Models / |
| Statement of responsibility, etc. | Aqsa Salih |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad: |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 71p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | Alzheimer's disease (AD) is a neurological condition characterized by persistent<br/>cognitive impairment with few treatment options available. Platelet-rich plasma<br/>(PRP) and platelet-rich growth factors (PRGF), produced from human blood, have<br/>shown promise in treating a variety of neurological disorders. However, their use in<br/>Alzheimer's disease is underexplored, particularly in chemically produced models.<br/>This study looks at the therapeutic potential of PRGF and PRP in a chemically<br/>induced Alzheimer's mouse model using aluminum chloride (AlCl3), with a<br/>particular emphasis on the novel use of intranasal PRGF administration. This study<br/>to explore and compare the effects of PRGF and PRP in an Alzheimer's disease<br/>chemical model. Behavioral assessments were performed to evaluate cognitive<br/>deficits, memory retention, and spatial learning. The Y-maze and Elevated Plus<br/>Maze (EPM) tests demonstrated significant cognitive improvements in the PRGFtreated mice. PRGF administration resulted in enhanced memory performance and<br/>cognitive flexibility, with higher number of alterations and entries to novel arm.<br/>Additionally, PRGF-treated mice exhibited reduced anxiety-like behavior in the<br/>EPM. These findings suggest that PRGF treatment significantly improves cognitive<br/>abilities and memory retention however do not fully restore and cannot be used<br/>confidently in treatment. Histological analysis of the frontal cortex, cerebral cortex,<br/>hippocampus, dentate gyrus (DG) region, and liver was conducted following<br/>behavioral assessments to There were no significant improvements in cellular<br/>integrity observed in either the PRGF or PRP treated groups, indicating less to no<br/>neuroprotection and potential reversal of AlCl3-induced damage. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Saima Zafar |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/50078">http://10.250.8.41:8080/xmlui/handle/123456789/50078</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 02/25/2025 | 610 | SMME-TH-1115 | Thesis |