Unlocking Neurogenesis: PRGF Regenerative Therapy and the role of Tau Protein in Neurodegenerative Disease Models / (Record no. 612947)

000 -LEADER
fixed length control field 02309nam a22001577a 4500
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 610
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Salih, Aqsa
245 ## - TITLE STATEMENT
Title Unlocking Neurogenesis: PRGF Regenerative Therapy and the role of Tau Protein in Neurodegenerative Disease Models /
Statement of responsibility, etc. Aqsa Salih
264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Islamabad:
Name of producer, publisher, distributor, manufacturer SMME- NUST;
Date of production, publication, distribution, manufacture, or copyright notice 2025.
300 ## - PHYSICAL DESCRIPTION
Extent 71p.
Other physical details Soft Copy
Dimensions 30cm
500 ## - GENERAL NOTE
General note Alzheimer's disease (AD) is a neurological condition characterized by persistent<br/>cognitive impairment with few treatment options available. Platelet-rich plasma<br/>(PRP) and platelet-rich growth factors (PRGF), produced from human blood, have<br/>shown promise in treating a variety of neurological disorders. However, their use in<br/>Alzheimer's disease is underexplored, particularly in chemically produced models.<br/>This study looks at the therapeutic potential of PRGF and PRP in a chemically<br/>induced Alzheimer's mouse model using aluminum chloride (AlCl3), with a<br/>particular emphasis on the novel use of intranasal PRGF administration. This study<br/>to explore and compare the effects of PRGF and PRP in an Alzheimer's disease<br/>chemical model. Behavioral assessments were performed to evaluate cognitive<br/>deficits, memory retention, and spatial learning. The Y-maze and Elevated Plus<br/>Maze (EPM) tests demonstrated significant cognitive improvements in the PRGFtreated mice. PRGF administration resulted in enhanced memory performance and<br/>cognitive flexibility, with higher number of alterations and entries to novel arm.<br/>Additionally, PRGF-treated mice exhibited reduced anxiety-like behavior in the<br/>EPM. These findings suggest that PRGF treatment significantly improves cognitive<br/>abilities and memory retention however do not fully restore and cannot be used<br/>confidently in treatment. Histological analysis of the frontal cortex, cerebral cortex,<br/>hippocampus, dentate gyrus (DG) region, and liver was conducted following<br/>behavioral assessments to There were no significant improvements in cellular<br/>integrity observed in either the PRGF or PRP treated groups, indicating less to no<br/>neuroprotection and potential reversal of AlCl3-induced damage.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element MS Biomedical Sciences (BMS)
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Supervisor : Dr. Saima Zafar
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://10.250.8.41:8080/xmlui/handle/123456789/50078">http://10.250.8.41:8080/xmlui/handle/123456789/50078</a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type Thesis
Holdings
Withdrawn status Permanent Location Current Location Shelving location Date acquired Full call number Barcode Koha item type
  School of Mechanical & Manufacturing Engineering (SMME) School of Mechanical & Manufacturing Engineering (SMME) E-Books 02/25/2025 610 SMME-TH-1115 Thesis
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