Exploring the Neuroprotective Effects of Indole Propionate and Shikonin in STZ-Induced Diabetic Rats: A Novel Therapeutic Strategy for Cognitive Impairment in Type 2 Diabetes Mellitus / (Record no. 613677)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02886nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asif, Muhammad |
| 245 ## - TITLE STATEMENT | |
| Title | Exploring the Neuroprotective Effects of Indole Propionate and Shikonin in STZ-Induced Diabetic Rats: A Novel Therapeutic Strategy for Cognitive Impairment in Type 2 Diabetes Mellitus / |
| Statement of responsibility, etc. | Muhammad Asif |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2025 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 91p. |
| Other physical details | Soft Copy |
| Dimensions | 30cm |
| 500 ## - GENERAL NOTE | |
| General note | The chronic metabolic disorder known as diabetes mellitus severely deteriorates memory<br/>function and learning while damaging hippocampal tissue. Given that impaired<br/>hippocampal insulin signaling leads to memory deficits, insulin resistance and<br/>hyperinsulinemia are considered critical links between type 2 diabetes mellitus (T2DM)<br/>and AD. This study utilized streptozotocin (STZ)-induced diabetic rat model to evaluate<br/>the therapeutic potential of indole propionate (IPA) and Shikonin as treatments for<br/>cognitive impairment. Male albino rats were divided into seven groups, three control<br/>groups receiving ddH₂O, IPA, and Shikonin, respectively, and four experimental groups<br/>treated with a high-fat diet and intraperitoneal (IP) injections of STZ (25 mg/kg) to<br/>induce diabetes. Following disease induction, diabetic rats were treated with IPA (40<br/>mg/kg), Shikonin (10 mg/kg), and metformin (200 mg/kg) for 28 days. The study<br/>measured three critical parameters which included body weight assessment together with<br/>blood glucose levels and evaluation of hippocampal and cortical gene expression analysis<br/>related to cognitive impairment. Real-time quantitative PCR (RT-qPCR) was utilized to<br/>evaluate mRNA expression levels of genes implicated in these deficits. Our findings<br/>demonstrate that the elevated expression of Tau and APP in diabetic rats was<br/>substantially reduced with IPA treatment (p < 0.0001). Additionally, PDIA3 (ERp57), an<br/>endoplasmic reticulum (ER)-resident chaperone, was significantly downregulated in the<br/>T2DM group but restored with IPA treatment. Dysregulated expression of the<br/>mitochondrial chaperone Hsp60 was also improved with both IPA and Shikonin. Insulindegrading enzyme (IDE), a key protein linking T2DM and AD, showed substantial<br/>restoration in the T2DM+IPA-treated group. IPA and Shikonin treatments improved the<br/>body weight and blood glucose levels of diabetic rats who experienced notable decreases<br/>in both parameters initially. The results of the study demonstrate how IPA and Shikonin<br/>show promise as treatments for reducing cognitive problems in diabetes patients.<br/>However, the clinical deployment of these compounds needs confirmation through<br/>additional studies at the cellular and molecular levels |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Saima Zafar |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/51750">http://10.250.8.41:8080/xmlui/handle/123456789/51750</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 05/08/2025 | 610 | SMME-TH-1127 | Thesis |