| 000 -LEADER |
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| fixed length control field |
02796nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Batool, Saima |
| 245 ## - TITLE STATEMENT |
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| Title |
Therapeutic Efficacy of Chrysoeriol in AlCl₃-Induced Mouse Model of Alzheimer Disease- Comparative Study / |
| Statement of responsibility, etc. |
Saima Batool |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Islamabad : |
| Name of producer, publisher, distributor, manufacturer |
SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice |
2025. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
102p. |
| Other physical details |
Soft Copy |
| Dimensions |
30cm |
| 500 ## - GENERAL NOTE |
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| General note |
Flavonoids are the most essential compounds for the establishment of next-generation<br/>therapeutic agents that are both clinically potent and effective in the treatment of<br/>neurodegenerative conditions. Chrysoeriol, a naturally occurring flavonoid, has powerful<br/>antioxidants, anti-inflammatory, and neuroprotective effects. Alzheimer's disease (AD) is a<br/>neurological ailment marked by progressive cognitive deterioration and memory loss. Current<br/>pharmaceutical treatments, such as acetylcholinesterase inhibitors and NMDA receptor<br/>antagonists, provide symptom alleviation but fail to halt the disease progression. The purpose of<br/>this study was to evaluate the therapeutic efficacy of chrysoeriol to two recognized AD<br/>medicines, galantamine and memantine, in an animal model. This research was designed to<br/>assess the potential neuroprotective effects of chrysoeriol in counteracting aluminum chlorideinduced AD on BALB/c mice. Aluminum is a neurotoxin that triggers oxidative stress, leading<br/>to neurological disorders. Mice were divided into a control group, an AlCl₃-induced AD model<br/>(20 mg/kg, orally), and a treatment group injected intraperitoneally with chrysoeriol (5 mg/kg),<br/>galantamine (1.25 mg/kg) and memantine (3 mg/kg). Cognitive function was evaluated using<br/>behavioral assessments including the Morris water maze, open field, elevated plus maze test, Ymaze test, and the novel object recognition test showed improved cognitive performance.<br/>Furthermore, effective defense against AlCl₃-induced dopaminergic degeneration was provided<br/>by treatment through improving the morphological and histological features of neurons in the<br/>hippocampus and cortex. Quantitative real-time PCR was employed to examine the expression of<br/>apoptosis-related genes namely (Bax and Bcl-2). The treatment of chrysoeriol exhibited<br/>comparable cognitive-improving effects of memantine and galantamine, it also demonstrated<br/>neuroprotective properties such as regulating the expression of genes included in apoptosis,<br/>mitigating oxidative stress, reducing neuronal damage, and modulating neurotransmitter levels.<br/>These results highlight the effectiveness of chrysoeriol and may offer a promising therapeutic<br/>adjunct to existing treatments. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Supervisor : Dr. Aneeqa Noor |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://10.250.8.41:8080/xmlui/handle/123456789/51856">http://10.250.8.41:8080/xmlui/handle/123456789/51856</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Thesis |
