NUST Institutions Library Catalogue

Depression is one of the most increasing psychological mood disorders, depression does not have
some specific physical symptoms, but it negatively affects the person mood, way of living and
thinking chronic mild stress (CMS) is one of its type, depression is affecting more than 300million
people in the world. Shortness of breath, headache, being miserable, stomach disturbance and
physical tensions are some of the common symptoms of depression that is reported according to
National Alliance of Mental Health, Anti-depressant are used for altering the neurotransmitters
those are serotonin, dopamine and norepinephrine that are primarily involved in regulating and
mood alleviating mood. Despite the availability of large number of drugs, many of patients are
resistant to the current mode of treatment that are available now adays. The obstacle that is
significant for the transportation of beneficial therapeutic entities to the nervous system is BBB
that is the blood brain barrier. There are junctions that are present in the endothelial cells of the
blood brain barrier that stop the drugs passage. Now nanoparticles are receiving significant
limelight owing to their small size and efficient brain targeting activity, making them likely to
cross the blood brain barrier while carrying the intact drug molecule otherwise incapable of
permeation. In this study the fluoxetine loaded liposomal nanoparticle coated with PEG were
developed to transport the drug across the BBB to the central nervous system having much greater
efficiency. For testing its delivery, the animal that is mice model of depression is used with the
specific name that is designed in order to induce depression like symptoms in mice. Before and
After treatment great differences between the physical behaviors like Elevated maze, open field
test, force swim test etc and sucrose consumption test were identified and plotted, as liposomes
that having capabilities to carry the anti-depressant drug molecule that is administered through the
Oral route of administration or the better and improved method of treatment.