The biology of the TGF-[Beta] family /
edited by Rik Derynck, University of California, San Francisco, Kohei Miyazono, The University of Tokyo.
- x, 1164 pages : illustrations (some color) ; 26 cm
Includes bibliographical references.
Machine generated contents note: -- (preliminary) -- 1. The discovery and early days of TGF-Beta: a historical perspective. -- Hal Moses, Anita Roberts, Rik Derynck -- 2. TGF-Beta and the TGF-Beta family, context-dependent roles in cell and tissue physiology -- Kohei Miyazono, Rik Derynck -- 3. Activins and inhibins -- Chester Brown -- 4. Bone morphogenetic proteins -- Takenobu Katagiri, Tetsu Watabe -- 5. Regulation of the bioavailability of TGF-Beta and TGF-Beta-related proteins -- Dan Rifkin -- 6. Agonists and antagonists of TGF-Beta family ligands -- Chenbei Chang -- 7. TGF-Beta family receptors -- Calle Heldin and Aris Moustakas -- 8. TGF-Beta signaling from receptors to Smads -- Akiko Hata, Ye-Guang Chen -- 9. Transcriptional control by Smads -- Caroline Hill -- 10. Post-translational control of Smads -- Xin-Hua Feng -- 11. Regulation of TGF-Beta family signaling by inhibitory Smads -- Keiji Miyazawa, Kohei Miyazono -- 12. Structural basis of ligand-receptor interactions -- Andrew Hinck, Thomas Müller, Tim Springer -- 13. Structural basis of intracellular signaling process: receptors and Smads -- Alex Bullock -- 14. Non-Smad TGF-Beta family signaling -- Ying Zhang -- 15. Signaling crosstalk in TGF-Beta signaling -- Kunxin Luo -- 16. TGF-Beta family signaling in the control of cell proliferation and survival -- Xiao-Fan Wang -- 17. TGF-Beta family signaling in Drosophila -- Mike O'Connor -- 18. TGF-Beta family signaling in C. elegans -- Cathy Savage-Dunn, Rick Padgett -- 19. TGF-Beta family signaling in early vertebrate development -- Liz Robertson -- 20. TGF-Beta family signaling in embryonic and somatic stem cell renewal and differentiation -- Jeff Wrana, Alan Mullen -- 21. TGF-Beta family signaling in epithelial differentiation and epithelial-mesenchymal transition -- Aris Moustakas -- 22. TGF-Beta family signaling in mesenchymal differentiation -- Brendan Lee, Yuji Mishina -- 23. TGF-Beta family signaling in endothelial cell differentiation, vasculogenesis and angiogenesis -- Peter ten Dijke -- 24. TGF-Beta family signaling in the control of hematopoiesis -- Stefan Karlsson, Ulrika Blank -- 25. TGF-Beta family signaling in lymphocyte and immune cell differentiation and function -- Shomyseh Sanjabi and Ming Li -- 26. TGF-Beta family signaling in neural and neuronal differentiation, development and function -- John Kessler -- 27. Control of the reproductive system by TGF-Beta family signaling -- Stephanie Pangas, Martin Matzuk -- 28. TGF-Beta family signaling in connective tissue and skeletal diseases -- Eileen Shore, Hal Dietz -- 29. TGF-Beta family signaling in tumor suppression and cancer progression -- Joan Seoane and Roger Gomis -- 30. TGF-Beta signaling and the tumor micro-environment -- Hal Moses -- 31. TGF-Beta signaling and fibrosis -- Hal Chapman -- 32. TGF-Beta-based therapeutical approaches -- Lalage Wakefield, Rosemary Akhurst -- 33. Activin/myostatin-based therapeutic approaches -- Se-Jin Lee, HQ Han -- 34. BMP-based therapeutic approaches -- Vicki Rosen.
" Members of the transforming growth factor b (TGFb) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. This books provides a comprehensive view of the different members of the TGFb family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer. "-- "Members of the transforming growth factor β (TGFβ) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. This book provides a comprehensive view of the different members of the TGFβ family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer"--
9781621820369 (hardback)
2016036867
Transforming growth factors-beta. SCIENCE / Life Sciences / Biology / Developmental Biology. SCIENCE / Life Sciences / Biology / Molecular Biology. SCIENCE / Life Sciences / Cytology.