Bhatti, Rohama Makmas  <br/><br/>
Role of Nucleobindin 1 in Clozapine-Induced Neuroprotection in MPTP-Treated Mice Models / 
Rohama Makmas Bhatti 
 - 64p.  Soft Copy  30cm 
<br/><br/> A possible candidate for neuroprotection has recently been identified as NUCB1, a multifunctional<br/>protein involved in calcium homeostasis and stress response. In this work, the effect of coadministering clozapine and MPTP on the survival of dopaminergic neurons was assessed. To<br/>determine the degree of neuroprotection, histological analyses and behavioral evaluations were<br/>done. The expression and distribution of NUCB1 in the central nervous system of mice with a<br/>particular focus on the brain by using RT-PCR was analyzed. Our results showed that mice treated<br/>with MPTP had considerably different levels of NUCB1 expression in the brain than mice treated<br/>with clozapine. These findings provide interesting directions for future neuroprotective approaches<br/>in the setting of MPTP-induced neuronal injury and shed light on the possible therapeutic<br/>implications of NUCB1 in reducing neurodegeneration in Parkinson’s disease. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>MS Biomedical Sciences (BMS)
<br/><br/><label>Dewey Class. No.: </label>610