Analyzing The Hepatoprotective Effects Of Silymarin Encapsulated Pegylated Liposomal Nanoparticles And Vitamin D & E For Targeted Nafld Treatment In Wistar Rats /
Farhat Batool
- 78p. Soft Copy 30cm
Nanotechnology-based therapeutics have recently emerged as an inventive and optimistic replacement for traditional therapy. Currently, biocompatible materials are used to create nanoparticles and they have the potential to deliver drugs more precisely, either inactively by enhancing the drug nanocarriers' physicochemical characteristics or actively by applying homing technologies tailored to particular tissues or cells that enable disease site targeting while minimising side effects. Because of their ability to overcome a wide range of biomedical, biological or biophysical constraints, NPs can be developed as nanoplatforms for efficient drug delivery. Silymarin has a diverse set of in vitro and in vivo actions, including antioxidant, antiinflammatory, dose-dependent anti-apoptotic, and cell transporter altering properties. As a result, it has the potential to be a promising medication in alternative medicine. However, oral silymarin has a low bioavailability, which restricts its medical applications. But the bioavailability of silymarin can be increased by using liposomes as drug delivery systems. In the current study, the silymarin-loaded pegylated liposomal nanoparticle was successfully created and employed as a treatment for NAFLD. Liposomal NPs can be created as nanoplatforms for the effective and targeted delivery of drugs due to their ability to pass through a number of biological, biophysical, and biomedical barriers To overcome the drawbacks, silymarin encapsulated liposome nanoparticles were synthesized utilizing DPPE by the ‘thin film hydration method’ and used against liver cirrhosis for the first time. To enhance the stability, Polyethylene glycol (PEG) was used to enhance stability and for inducing the stealth effect, by coating the liposomes nanoparticles. Pegylation enhances the steric repulsion and is hence known a as better stabilizer for different types of nanoparticles. PEG follows the erosion-controlled release mechanisthe m of drug that resulta ed in sustained release. Hence, it is noteworthy that encapsulating the silymarin drug within liposomes and tailoring these liposome nanoparticles by PEG, is a substantial strategy to combat NAFLD.