TY  - BOOK
AU  -  Sajjad ,Aleena
AU  - Supervisor: Dr. Adeeb Shehzad
TI  - Saikosaponin B2 Protects Against LPS Induced Inflammation In Neuronal Cell Lines
U1  - 610 
PY  - 2024///
CY  - Islamabad : 
PB  - SMME- NUST; 
KW  - MS Biomedical Sciences (BMS)
N1  - This study explores the protective effects of Saikosaponin B2, a triterpenoid extracted from the roots of Radix bupleurum against lipopolysaccharide-induced inflammation, a common model for studying neurodegenerative diseases. LPS induces strong immune reactions, activating pro-inflammatory cytokines, increases ROS generation, ultimately leading to neuronal damage and loss. We theorized that Saikosaponin B2 holds an anti-inflammatory and anti-oxidant profile capable of mitigating LPS-induced effects. An in-vitro model was used to determine the extract’s effectiveness in reducing inflammatory gene expression, ROS generation and activation of injury mechanisms. Our results show that Saikosaponin B2 reduces LPS-induced inflammation, signifying its possible utilization as a therapeutic agent against neurodegenerative diseases
UR  -  http://10.250.8.41:8080/xmlui/handle/123456789/46178
ER  -