Batool, Saima  <br/><br/>
Therapeutic Efficacy of Chrysoeriol in AlCl₃-Induced Mouse Model of Alzheimer Disease- Comparative Study / 
Saima Batool 
 - 102p.  Soft Copy  30cm 
<br/><br/> Flavonoids are the most essential compounds for the establishment of next-generation<br/>therapeutic agents that are both clinically potent and effective in the treatment of<br/>neurodegenerative conditions. Chrysoeriol, a naturally occurring flavonoid, has powerful<br/>antioxidants, anti-inflammatory, and neuroprotective effects. Alzheimer's disease (AD) is a<br/>neurological ailment marked by progressive cognitive deterioration and memory loss. Current<br/>pharmaceutical treatments, such as acetylcholinesterase inhibitors and NMDA receptor<br/>antagonists, provide symptom alleviation but fail to halt the disease progression. The purpose of<br/>this study was to evaluate the therapeutic efficacy of chrysoeriol to two recognized AD<br/>medicines, galantamine and memantine, in an animal model. This research was designed to<br/>assess the potential neuroprotective effects of chrysoeriol in counteracting aluminum chlorideinduced AD on BALB/c mice. Aluminum is a neurotoxin that triggers oxidative stress, leading<br/>to neurological disorders. Mice were divided into a control group, an AlCl₃-induced AD model<br/>(20 mg/kg, orally), and a treatment group injected intraperitoneally with chrysoeriol (5 mg/kg),<br/>galantamine (1.25 mg/kg) and memantine (3 mg/kg). Cognitive function was evaluated using<br/>behavioral assessments including the Morris water maze, open field, elevated plus maze test, Ymaze test, and the novel object recognition test showed improved cognitive performance.<br/>Furthermore, effective defense against AlCl₃-induced dopaminergic degeneration was provided<br/>by treatment through improving the morphological and histological features of neurons in the<br/>hippocampus and cortex. Quantitative real-time PCR was employed to examine the expression of<br/>apoptosis-related genes namely (Bax and Bcl-2). The treatment of chrysoeriol exhibited<br/>comparable cognitive-improving effects of memantine and galantamine, it also demonstrated<br/>neuroprotective properties such as regulating the expression of genes included in apoptosis,<br/>mitigating oxidative stress, reducing neuronal damage, and modulating neurotransmitter levels.<br/>These results highlight the effectiveness of chrysoeriol and may offer a promising therapeutic<br/>adjunct to existing treatments. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>MS Biomedical Sciences (BMS)
<br/><br/><label>Dewey Class. No.: </label>610