000			02060nam a22001577a 4500
082			_a610
100			_aTariq, Faiza _9120001
245			_aSynthesis, Characterization and Application Of Natural Nano Composites / _cFaiza Tariq
264			_aIslamabad : _bSMME- NUST; _c2023.
300			_a71p. _bSoft Copy _c30cm
500			_aThe use of natural polymers in the creation of skin wound dressings has gained attentionfor its potential to speed up healing and protect against pathogens. In this study, theability of the Papaver somniferum plant to heal wounds in various forms, suchas pureplant extract, plant-derived silver nanoparticles, and their inclusion in a polyvinyl alcohol hydrogel, was investigated. Characterization of the compounds was done usingUVspectrophotometry, X-ray diffraction, Fourier transform infrared spectroscopy, scanningelectron microscopy, and energy dispersive spectroscopy. Antimicrobial tests showedthat silver nanoparticles had a zone of inhibition of 12mm against Staphylococcus aureus, while the silver nanoparticle hydrogel had a zone of inhibition of 23mmagainst Klebsillapneumonia. The zone of inhibition by the plant extract was 11mmagainst Staphylococcus aureus, while the plant extract gel had a zone of inhibition of 16mmagainst Staphylococcus aureus. The results suggest that the bio-composite patches createdfrom these materials have potential to work against both gram-positive andgram-negative bacteria. In a mouse model, the wound healing capacity was highest for thesilver nanoparticle gel, with a wound closure of 1.7mm. Histological analysis alsoshowed that the silver nanoparticle hydrogel had excellent wound repair properties. Overall, the study suggests that pure AgNPs and bio-composite hydrogel of AgNPs haveefficient and quick healing of wounds as compared to the plant extract and plant nanocomposites hydrogel.
650			_aMS Biomedical Sciences (BMS)
700			_aSupervisor : Dr. Adeeb Shehzad _9119503
856			_uhttp://10.250.8.41:8080/xmlui/handle/123456789/32415
942			_2ddc _cTHE
999			_c607469 _d607469