| 000 | 01388nam a22001697a 4500 | ||
|---|---|---|---|
| 003 | NUST | ||
| 082 | _a610 | ||
| 100 |
_a Sajjad ,Aleena _95093 |
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| 245 |
_aSaikosaponin B2 Protects Against LPS Induced Inflammation In Neuronal Cell Lines / _cAleena Sajjad |
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| 264 |
_aIslamabad : _bSMME- NUST; _c2024. |
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| 300 |
_a76p. ; _bSoft Copy _c30cm. |
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| 500 | _aThis study explores the protective effects of Saikosaponin B2, a triterpenoid extracted from the roots of Radix bupleurum against lipopolysaccharide-induced inflammation, a common model for studying neurodegenerative diseases. LPS induces strong immune reactions, activating pro-inflammatory cytokines, increases ROS generation, ultimately leading to neuronal damage and loss. We theorized that Saikosaponin B2 holds an anti-inflammatory and anti-oxidant profile capable of mitigating LPS-induced effects. An in-vitro model was used to determine the extract’s effectiveness in reducing inflammatory gene expression, ROS generation and activation of injury mechanisms. Our results show that Saikosaponin B2 reduces LPS-induced inflammation, signifying its possible utilization as a therapeutic agent against neurodegenerative diseases. | ||
| 650 | _aMS Biomedical Sciences (BMS) | ||
| 700 |
_aSupervisor: Dr. Adeeb Shehzad _9119503 |
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| 856 | _u http://10.250.8.41:8080/xmlui/handle/123456789/46178 | ||
| 942 |
_2ddc _cTHE |
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| 999 |
_c611381 _d611381 |
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