Evaluation of the anti-cancerous effect of ciprofloxacin loaded liposomes against leukemia in rat model / (Record no. 607175)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02775nam a22001577a 4500 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Fatima, Sahar |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of the anti-cancerous effect of ciprofloxacin loaded liposomes against leukemia in rat model / |
| Statement of responsibility, etc. | Sahar Fatima |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Islamabad : |
| Name of producer, publisher, distributor, manufacturer | SMME- NUST; |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 86p. |
| Dimensions | 30cm |
| Other physical details | Soft Copy |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Acute myeloid leukemia is an aggressive type of leukemia with a high mortality rate.It involves the<br/>anomalous proliferation and differentiation of the hematopoietic cells. The biological and clinical<br/>disparity of this disorder makes treatment complex and emphasizes the need to explore novel<br/>therapeutic drug delivery systems. These carriers must exhibit less toxicity and more efficacy than the<br/>conventional chemotherapeutic drugs presently available against leukemia. In this study, the anticancer potential of Ciprofloxacin, which is a potent antibiotic as a free drug and as a liposomal<br/>nanoparticle, was investigated in benzene-induced leukemic rat model. The result of free<br/>ciprofloxacin and nanoparticles of ciprofloxacin was compared to free doxorubicin and nanoparticlesbased doxorubicin respectively as doxorubicin is well known anti-leukemia drug and is considered a<br/>positive control in this study. The liposomes are prepared by thin film hydration method and are<br/>pegylated to improve cell internalization of drug. Characterization of nanoparticles was done by<br/>SEM, UV, Zeta potential and FTIR analysis. The biological activity of doxorubicin, ciprofloxacin<br/>and nanoparticles of ciprofloxacin and doxorubicin was tested by different cytotoxicity and<br/>antioxidant assays. The free drug and nanoparticles were then administered by intravenous route to<br/>benzene induced leukemic rat model, to investigate its anti- leukemic potential. For this purpose,<br/>different parameters were analyzed including hematological profiles, morphology of blood cells,<br/>hepatic & renal enzyme activity in samples obtained from the experimental groups. It was observed<br/>in biological assays that free drugs have higher cytotoxicity as compared to nanoparticles of drugs. It<br/>was observed in rat model that ciprofloxacin has remarkable recovery of cellular indicators as<br/>compared to leukemic conditions. The result of liposomal ciprofloxacin is as significant as that of<br/>doxorubicin liposomes. The blood cell counts of Ciprofloxacin-treated leukemic rats improved, as did<br/>hepatic and renal biomarker levels. whereas additional research is required to assess the efficacy of<br/>ciprofloxacin liposomal chemotherapy against leukemia. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MS Biomedical Sciences (BMS) |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Supervisor : Dr. Nosheen Fatima Rana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://10.250.8.41:8080/xmlui/handle/123456789/40360">http://10.250.8.41:8080/xmlui/handle/123456789/40360</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Thesis |
| Withdrawn status | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Koha item type |
|---|---|---|---|---|---|---|---|
| School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 12/06/2023 | 610 | SMME-TH-947 | Thesis |