Role of Nucleobindin 1 in Clozapine-Induced Neuroprotection in MPTP-Treated Mice Models / Rohama Makmas Bhatti
Material type:
TextIslamabad : SMME- NUST; 2023Description: 64p. Soft Copy 30cmSubject(s): MS Biomedical Sciences (BMS)DDC classification: 610 Online resources: Click here to access online Summary: A possible candidate for neuroprotection has recently been identified as NUCB1, a multifunctional
protein involved in calcium homeostasis and stress response. In this work, the effect of coadministering clozapine and MPTP on the survival of dopaminergic neurons was assessed. To
determine the degree of neuroprotection, histological analyses and behavioral evaluations were
done. The expression and distribution of NUCB1 in the central nervous system of mice with a
particular focus on the brain by using RT-PCR was analyzed. Our results showed that mice treated
with MPTP had considerably different levels of NUCB1 expression in the brain than mice treated
with clozapine. These findings provide interesting directions for future neuroprotective approaches
in the setting of MPTP-induced neuronal injury and shed light on the possible therapeutic
implications of NUCB1 in reducing neurodegeneration in Parkinson’s disease.
| Item type | Current location | Home library | Shelving location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|---|---|
Thesis
|
School of Mechanical & Manufacturing Engineering (SMME) | School of Mechanical & Manufacturing Engineering (SMME) | E-Books | 610 (Browse shelf) | Available | SMME-TH-938 |
A possible candidate for neuroprotection has recently been identified as NUCB1, a multifunctional
protein involved in calcium homeostasis and stress response. In this work, the effect of coadministering clozapine and MPTP on the survival of dopaminergic neurons was assessed. To
determine the degree of neuroprotection, histological analyses and behavioral evaluations were
done. The expression and distribution of NUCB1 in the central nervous system of mice with a
particular focus on the brain by using RT-PCR was analyzed. Our results showed that mice treated
with MPTP had considerably different levels of NUCB1 expression in the brain than mice treated
with clozapine. These findings provide interesting directions for future neuroprotective approaches
in the setting of MPTP-induced neuronal injury and shed light on the possible therapeutic
implications of NUCB1 in reducing neurodegeneration in Parkinson’s disease.
There are no comments on this title.